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总结

多家媒体报道称,研究人员提出阿尔茨海默病的新治疗思路:药物与干预应重点瞄准APOE基因这一主要风险驱动因素。相关研究指出,APOE4与APOE3等变体与相当比例病例相关,可能解释多数患者的遗传易感性;在实验模型中,调整或“翻转”该风险基因后,部分典型病理特征出现逆转迹象。研究团队认为,这一发现或推动更聚焦的预防与治疗策略,但其临床有效性与安全性仍需更大规模人群研究和临床试验验证。

正文

Alzheimer's therapies should target a particular gene, researchers say The Guardian Scientists Flip an Alzheimer's Risk Gene - and Reverse Key Hallmarks of the Disease SciTechDaily APOE gene: A major driver in Alzheimer's disease News-Medical APOE4 and APOE3 gene variants linked to at least 7 in 10 Alzheimer's cases, study suggests Alzheimer's Research UK Most Alzheimer's cases linked to a single gene, study finds The Independent
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